李文均

李文均,男,博士,中山大学生命科学大学院/生态与进化学院教授,2014年度百人计划 /珠江学者入选者,博士生导师;国际原核生物系统学委员会(International Committee on Systematics of Prokaryotes,ICSP)国际委员;伯杰氏国际系统微生物学会(BISMiS)创始会员、美国微生物学会(American Society for Microbiology)会员、美国地球科学学会(American Geosciences Union)会员、国际极端环境微生物学会(International Society for Extremophiles)会员。

中国微生物学会理事,中国微生物学会普及及教育工作委员会委员、环境微生物专业微生物委员会、微生物资源专业委员会委员《Antonie van Leeuwenhoek》、《The Scientific World Journal》、《Frontiers in Marine Systematics and Taxonomy》、《BioMed Research International》、《BISMiS Bulletin》、《微生物学报》等多个杂志编委及多个国内外期刊的通讯评审专家。

2012.08-2014.07 任云南省"特殊生境微生物资源开发与利用国际联合研究中心"负责人

2014.07-至今 中山大学生命科学大学院/生态与进化学院百人计划/珠江学者特聘教授,博士生导师。

人物经历

1992-1996年就读于河南师范大学生命科学学院,获理学学士

1996-1999年就读于云南大学微生物研究所,获理学硕士学位;

1999-2002年就读于中科院沈阳应用生态研究所,获理学博士学位。

1999-2014年,云南大学生命科学学院工作,先后任实习研究员、助理研究员、研究员(2004年起)。

2000年赴日本北里研究所做访学;2003、2005、2007赴韩国生命工学研究院做访问;

2006-2007年在美国佐治亚大学、2015年在美国内华达大学做访问学者。

2005年入选教育部新世纪优秀人才,2011年入选中国科学院百人计划(B类);

2014年7月入选中山大学百人计划、广东省珠江学者特聘教授。

研究兴趣

重点开展各种极端(高温、低温、高盐碱)环境或特殊环境(植物内生或海洋)下的原核生物(重点是放线菌)资源的收集、保育及生态学、系统分类学等方面的基础研究,以及服务我国微生物药物前期开发(微生物菌株选育、活性筛选、代谢产物化学)及工业用酶菌株筛选等应用基础研究。

科研经历

自1996年以来,一直致力于原核微生物资源的研究工作,重点开展极端环境或各种特殊环境(植物内生或海洋)下的原核微生物(重点是放线菌)资源的收集、保存及生态学、系统分类学及其应用价值评估(活性筛选、代谢产物化学及酶学等)等方面的研究;

2000.06-10在日本北里研究所生物机能研究中心从事放线菌和极端环境下的放线菌分离、系统分类合作研究;

2003.10-2004.02,2005.08-10, 2007.03先后三次赴韩国国家生命工学研究院等单位从事嗜盐放线细菌分离及系统分类学合作或博士后研究;

2005年12月 入选教育部“新世纪优秀人才”支持计划

2006.04-2007.3 作为博士后/高级访问学者受邀在美国佐治亚大学微生物学系、海洋生物科学系进行合作研究工作,主要开展自氧和异氧微生物的分离及系统学研究,同时运用分子生物学手段开展热泉沉积物微生物CO固定途径关键酶克隆文库的构建等分子生态学研究;

2008.08-2014.07 云南大学放线菌资源与利用省创新团队负责人;

2009.09-2010.09 由云南省委组织部选派到中科院微生物研究所做“西部之光”做访问学者一年;

2009.01-2011.12 任云南大学省微生物研究所副所长,主管科研、重点学科和重点实验室建设;

2011.09-至今任云南省高校“放线菌资源与利用”重点实验室主任;

2012.01-至今任云南大学生命科学学院副院长,主管研究生工作、学科建设等;

2012.08-2014.07 任云南省“特殊生境微生物资源开发与利用国际联合研究中心”负责人

2014.07-至今 中山大学生命科学大学院/生态与进化学院百人计划/珠江学者特聘教授,博士生导师

科研项目

主持并顺利完成5项国家自然科学基金项目,1 项教育部“新世纪优秀人才支持计划”专项基金、1 项云南省创新团队项目,2项国际合作项目,1 项教育部科学技术研究重点项目、1 项教育部留学归国人员科学启动基金、2项云南省自然科学基金项目、2 项云南省人才专项基金、1 项中国博士后科学基金、2 项云南省教育厅基金项目;

以主要骨干参与完成2 项国家973项目子课题 [“极端微生物的生物多样性及潜在应用价值评估” (2004-2009)、“海洋微生物次生代谢的生理生态效应及其生物合成机制”(2010-2014)]、科技部国际合作专项1项(极端微生物环境中的新药发现)、国家科技部重大基础研究(973)前期项目1项(云南放线菌、高等真菌和野生蔬菜的资源评价与可持续利用)、1项国家自然科学基金重点项目(通过进化生物学途径从植物共生放线菌中寻找强生理活性化合物) 、国家自然科学基金项目2项,云南省重点项目1项、云南省国际合作项目3项、云南省自然科学基金2项;

现主持 1项科技部国际合作重点项目“中国西部热泉微生物资源及其功能利用合作研究”(2013DFA31980),1项国家自然科学基金项目,2 项省级科研项目,及多项横向合作课题。

指导学生

指导毕业博士后2名、博士生5名,硕士生29名,正在指导的硕士研究生15名,博士研究生7名。另外,曾与其他同行指导3名韩国访问学者、4名印度博士生、1名埃及博士生、1名马来西亚大学博士生。

所获奖励

2003年10月获“云南大学伍达观教育基金第七届优秀教师奖”优秀奖

2003年11月,参与撰写论文《Streptomonosporasalinagen.nov.,sp.nov.,a new member of the familyNocardiopsaceae》被云南省科学技术协会评为云南省优秀科学论文红云奖一等奖

2004年分别被云南省教育厅评为“云南省高等学校教学、科研学术带头人”、云南省科技厅评为“云南省中青年学术和技术带头人后备人才”;

2005年2月获得2004年度云南省自然科学奖一等奖“放线菌资源研究”(获奖人员排名:徐丽华,崔晓龙,李文均,李铭刚,文孟良彭谦,徐平,张华,姜成林,刘志恒,张利平)   ;

2005年11月,第一作者撰写的论文《Yania halotoleransgen. nov., sp. nov., a novel member of the suborderMicrococcineaeisolated from saline soil in China》被云南省科学技术协会评为“第七届云南省优秀科学论文云锡奖一等奖”;

2006年10月入选《微生物学报》新一届编辑委员会

2007年3月,指导的张玉琴同学的硕士学位论文“盐环境下革兰氏阳性细菌的分离和系统分类学研究”荣获2007年度云南省优秀硕士论文;

2007年10月,获得WFCC (The World Federationfor Culture Collections) Skerman Award for MicrobialTaxonomy (世界菌种保藏联合会为表彰在微生物分类领域做出杰出贡献的青年科学家而设立的以著名微生物分类学家V.B.D.Skerman教授来命名的奖项)   ;

2007年12月,获得云南省第五届科技红河奖;

2008年02月,作为第一作者撰写的论文《Proposal ofYaniaceaefam. nov. andYaniaflavasp. nov. and emendeddescription of the genusYania》被云南省科学技术协会评为“第八届云南省优秀科学论文云锡奖特等奖”;

2008年10月,获第八届“云南省十大杰出青年”提名奖

2009年4月获得2008年度云南省自然科学奖一等奖放线菌系统学研究”(获奖人员排名:李文均,张玉琴,唐蜀昆,职晓阳,姜怡,王永霞,田新朋,陈华红,赵立兴,段若玲,姜成林,徐丽华);

2010年1月获得教育部自然科学奖二等奖“新疆青海高盐环境可培养嗜盐放线菌多样性研究”(获奖人员排名:李文均,唐蜀昆,崔晓龙,职晓阳,姜成林,徐丽华);

2010年1月,撰写的论文“放线菌高级分类单元分类系统的更新及两个新亚目和四个新科的描述”荣获“第九届云南省优秀科技论文(云锡)奖”二等奖;

2011年5月,获“云南省青年五四奖章”提名奖

2011年3月,指导的吴晋元同学的硕士学位论文“云南黑井和江城盐矿沉积层土壤放线菌多样性研究”荣获2010年度云南省优秀硕士论文奖;

2012年5月,指导的李岩同学的硕士学位论文“白色普氏菌YIM 90005T四氢合成相关基因的克隆与分析”荣获2011年度云南省优秀硕士论文奖;

2012年10月,获“云南省有突出贡献优秀专业技术人才”(省突)称号;

2012年12月,获云南大学2012年度“红云园丁奖”优秀教师奖;

2013年04月,“云南省部分药用植物内生菌资源及活性代谢产物的研究”获得“云南省自然科学三等奖”(获奖人:徐丽华、吴少华、李文均,排名第三);

2013年,有两篇作为第一或通讯作者的学术论文入选ESI全球1%行列;

2014年,入选广东省珠江学者特聘教授人才计划。

科研成果

李文均教授长期围绕微生物资源与生态学方向,主要从事放线菌的系统分类、资源利用与生态学研究,创新性成果包括:(1)建立了针对多种特殊生境放线菌的分离方法,对我国西部地区放线菌资源进行系统分离并保存了5万余株放线菌;(2)先后发现、建立并生效发表了细菌、放线菌新目4个,江苏新科科技有限公司10个,新属30余个,新种300余个,显著提高了我国在该领域的国际地位;(3)与科研院所、企业广泛合作,资源共享,推动了特殊生境放线菌资源的活性筛选和次生代谢产物、酶学等研究;(4)对原核生物莽草酸通路起源和分子进化、极端环境微生物生态适应性机制进行了深入研究并取得积极进展

先后承担了包括国家科技部“973”子课题,973前期,国家科技部国际合作重点项目,国家自然科学基金等在内的30余项国家级或省级课题的研究,现在研主持1项科技部国际合作专项,1项国家自然科学基金面上项目,1 项省重点项目及部分横向合作课题。在Nat Commun, PLOS Biol, Environ Microbiol、BioresourceTechnol、Genome BiolEvol、MolPhylogenetEvol、Appl Environ Microbiol等杂志发表学术论文近600篇(其中SCI源刊论文480余篇),专著3部,受邀撰写新版伯杰氏系统细菌学手册(Bergey’s Manual of Systematic 细菌学)6章,新版原核生物(The Prokaryotes)2章,申请专利21件。另外,他还先后荣获云南省自然科学一等奖(2次,分别排名第一和第三)、教育部自然科学二等奖(排名第一)、云南省自然科学三等奖(排名第三)、云南省青年科技奖、云南大学伍达观优秀教师奖、云南省十大杰出青年提名奖、“云南省青年中国青年五四奖章”提名奖、云南省突出贡献专业技术人才等20余项奖励。

2015、2016连续三年入选由世界著名出版公司爱思唯尔(Elsevier)发布的中国高被引学者“免疫和微生物学”榜单。

代表论文

1.Wen-Jun Li*, Salam Nimaichand, Zhao Jiang, Min-Jiao Liu, Thi-Nhan Khieu, Chang-Jin Kim, Wael N.Hozzein, Dong-Jin Park, Mohammed A. M. Wadaan, Debananda S. Ningthoujam.链霉菌属 canchipurensissp. nov., isolated from a limestone habitat.Antonie Van Leeuwenhoek. 2014, Dec;106(6):1119-1126. doi: 10.1007/s10482-014-0281-6.

2. Bing-Bing Liu, Wan-Yu Zhao, Xiao Chu, Wael N.Hozzein, Deene Manik Prabhu, Mohammed A.M. Wadaan, Shu-Kun Tang, Li-Li Zhang andWen-Jun Li*.Haladaptatus pallidirubidus sp. nov., a halophilic archaeon isolated from saline soil samples in Yunnan and Xinjiang, China.Antonie Van Leeuwenhoek. 2014, Nov, 106(5):901-910. DOI 10.1007/s10482-014-0259-4;

3. Yu Zhou, Rui Li, Xiao-Yang Gao, Alla Lapidus, James Han, Matthew Haynes, Elizabeth Lobos, Marcel Huntemann, Amrita Pati, Natalia N. Ivanova, Manfred Rohde, Konstantinos Mavromatis, Brian J. Tindall, Victor Markowitz, Tanja Woyke, Hans-Peter Klenk*, Nikos C. Kyrpides andWen-Jun Li*. High quality draft genome sequence of the slightly halophilic bacterium Halomonas zhanjiangensis type strain JSM 078169T (DSM 21076T) from a sea urchin in southern China.Standards in Genomic Sciences. (2014) 9: 1020-1030. DOI:10.4056/sigs.5449586;

4. En-Min Zhou, Tian-Tian Yu, Lan Liu, Hong Ming, Yi-Rui Yin, Lei 越南盾, Min Tseng, Guo-Xing Nie, andWen-Jun Li*.Geothermomicrobium terrae gen. nov., sp. nov., a novel member of the familyThermoactinomycetaceae.Int. J. Syst. Evol. Microbiol.2014,64(9): 2998-3004;published ahead of printJune 6, 2014,doi:10.1099/ijs.0.059766-0;

5. Dao-Feng Zhang, Jing-Mei Zhong, Xiao-Mei Zhang, Zhao Jiang, En-Min Zhou, Xin-Peng Tian, Si Zhang, andWen-Jun Li*.Nocardioides nanhaiensis sp. nov. an actinobacterium isolated from a marine sediment sample.Int. J. Syst. Evol. Microbiol.2014, 64(8):2718-2722. doi: 10.1099/ijs.0.062851-0.;

6. Dao-Feng Zhang, Zhao Jiang, Xiao-Mei Zhang, Ling-Ling Yang, Xin-Peng Tian, Li-Juan Long, Si Zhang, andWen-Jun Li*.Actinophytocola sediminissp. nov., a novel actinomycete isolated from a marine sediment.Int. J. Syst. Evol. Microbiol.2014 , 64(8):2834-2840. doi: 10.1099/ijs.0.062638-0.;

7. Kyrpides NC,Hugenholtz P,Eisen JA,Woyke T,Göker M,Parker CT,Amann R,Beck BJ,Chain PS,Chun J,Colwell RR,Danchin A,Dawyndt P,Dedeurwaerdere T,DeLong EF,Detter JC,De Vos P,Donohue TJ,Dong XZ,Ehrlich DS,Fraser C,Gibbs R,Gilbert J,Gilna P,Glöckner FO,Jansson JK,Keasling JD,卓定 R,Labeda D,Lapidus A,Lee JS,Li WJ,Ma J,Markowitz V,Moore ER,Morrison M,Meyer F,Nelson KE,Ohkuma M,Ouzounis CA,Pace N,Parkhill J,Qin N,Rossello-Mora R,Sikorski J,Smith D,Sogin M,Stevens R,Stingl U,Suzuki KI,Taylor D,Tiedje JM,Tindall B,Wagner M,Weinstock G,Weissenbach J,White O,Wang J,Zhang L,Zhou YG,Field D,Whitman WB,Garrity GM,Klenk HP. Genomic Encyclopedia of Bacteria and 古菌: Sequencing a Myriad of Type Strains. PLoS Biol.2014 Aug 5;12(8):e1001920. doi: 10.1371/journal.pbio.1001920. eCollection 2014.

8. Shan-Hui Li, Yi Jin, Juan Cheng, Dong-Jin Park, Chang-Jin Kim, Wael N.Hozzein, Mohammed A.M. Wadaan, Wen-Sheng Shu, Lin-Xian Ding,Wen-Jun Li*.Gordonia jinhuaensis sp. nov., a novel actinobacterium, isolated from a VBNC (viable but non-culturable) state in pharmaceutical waste液态水Antonie Van Leeuwenhoek.2014, Aug, 106:347–356, DOI 10.1007/s10482-014-0207-3.;

9. Yan-Yan Duan, Hong Ming, Lei Dong, Yi-Rui Yin, Yi Zhang, En-Min Zhou, Lan Liu, Guo-Xing Nie,Wen-Jun Li*.链霉菌属 calidiresistens sp. nov., isolated from a hot spring sediment.Antonie Van Leeuwenhoek. 2014, 106:189–196, DOI 10.1007/s10482-014-0180-x;

10. Juan Cheng, Hong-Fei Wang, Li Li, Wei Chen, Yan-Qing Duan, Bao-Ling Duan, Xin-Hua Lu, Yan-Bo Ding, andWen-Jun Li*.Tomitella cavernea sp. nov., a novel actinomycete isolated from the Jiuxiang Scenic Region in Yunnan, south-west China.Int. J. Syst. Evol. Microbiol.2014 Jul;64(Pt 7): 2319-2323. doi: 10.1099/ijs.0.060202-0.;

11. Xiao-Yang Gao, Xiao-Yang Zhi, Hong-Wei Li, Hans-Peter Klenk,Wen-Jun Li*. Comparative genomics of the bacterial genus 链球菌 illuminates evolutionary implications of 物种 groups.PLoS One. 2014, 9(6): e101229. doi:10.1371/journal.pone.0101229.

12. Xu L, Zeng XC, Nie Y, Luo X, Zhou E, Zhou L, pan Y,Li W.Pontibacter diazotrophicus sp. nov., a Novel Nitrogen-Fixing Bacterium of the Family Cytophagaceae.PLoS One. 2014 Mar 19;9(3):e92294. doi: 10.1371/journal.pone.0092294. eCollection 2014.

13. Kaihui Liu, Xiaowei Ding, Hong-Fei Wang, Xiaomei Zhang, Wael N.Hozzein, Mohammed A.M. Wadaan,Afeng Lan, Bo Zhang,Wenjun Li*. Eukaryotic microbial communities in hypersaline soils and sediments from the alkaline hypersaline Huama Lake as revealed by 454 pyrosequencing.Antonie Van Leeuwenhoek. 2014, May;105(5):871-80. doi: 10.1007/s10482-014-0141-4;

14. Xiao-Yang Zhi, Ji-Cheng Yao, Hong-Wei Li, Ying Huang,Wen-Jun Li*. Genome-wide identification, domain architectures and phylogenetic analysis provide new insights into the early evolution of shikimate pathway in 原核生物Molecular Phylogenetics and Evolution. 2014, 75:154-164. doi: 10.1016/j.ympev.2014.02.015;

15. Xiao-Yang Zhi, Ji-Cheng Yao, Shu-Kun Tang, Ying Huang, Hong-Wei Li,Wen-Jun Li*. The futalosine pathway played an important role in menaquinone biosynthesis during early prokaryote 翼豪陆神Genome Biology and Evolution 2014, Jan; 6(1):149-60. doi: 10.1093/gbe/evu007;

16. Jessica K. Cole, Brandon A. Gieler, devon L. Heisler, Maryknoll M. Palisoc, Amanda J. Williams, Alice C. Dohnalkova, Hong Ming, Tian Tian Yu, Jeremy A. Dodsworth,Wen-Jun Li, and Brian P. Hedlund*.Kallotenue papyrolyticum gen. nov., sp. nov., a cellulolytic and filamentous thermophile isolated from Great Boiling Spring that represents a novel lineage (Kallotenualesord. nov.,Kallotenuaceae fam. nov.) within the classChloroflexia.Int. J. Syst. Evol. Microbiol.2013, 63(12): 4675–4682;

17. Dao-Feng Zhang, Hua-Qi pan, Jie He, Xiao-Mei Zhang, Yong-Guang Zhang, Hans-Peter Klenk, Jiang-Chun Hu \u0026Wen-Jun Li*. Description ofStreptomonospora sediminissp. nov. andStreptomonospora nanhaiensis sp. nov., and reclassification of拟诺卡氏菌属 arabia (Hozzein \u0026 Goodfellow, 2008) asStreptomonospora arabica comb. nov. and emended description of the genusStreptomonospora.Int. J. Syst. Evol. Microbiol.2013, 63(12): 4447–4455;

18. Tian-Tian Yu, Ji-Cheng Yao, Yi-Rui Yin, Ling-Ling Yang, Shu-Kun Tang, Hong Ming, En-Min Zhou and Wen-jun Li*.Rehaibacterium terraegen. nov., sp. nov. isolated from a geothermally heated soil sample in Tengchong, Yunnan, south-west China.Int. J. Syst. Evol. Microbiol.2013, 63(12): 4058-4063;

19. Dao-Feng Zhang, Xiu Chen, Xiao-Mei Zhang, Xiao-Yang Zhi, Ji-Cheng Yao, Yi Jiang, Zhi Xiong, andWen-jun Li*.Mycobacterium sediminis sp. nov. andMycobacterium arabiensesp. nov., two novel rapidly growing members of the genusMycobacterium.Int. J. Syst. Evol. Microbiol.2013, Nov; 63(11):4081-4086. doi: 10.1099/ijs.0.050567-0;

20. Zhao-Qi Song, Li-Wang, Feng-Ping Wang, Hong-Chen Jiang, JinQuan Chen, En-Min Zhou, Feng Liang, Xiang Xiao, andWen-Jun Li*. Abundance and diversity of archaeal accA gene in Hot Springs in Yunnan Province, China.Extremophiles.2013, 17:871-879;

21. Tian-Tian Yu, En-Min Zhou, Yi-Rui Yin, Ji-Cheng Yao, Hong Ming, Lei 越南盾, Shuai Li, Guo-Xing Nie andWen-jun Li*.Vulcaniibacterium tengchongense gen. nov., sp. nov. isolated from a geothermally heated soil sample, and reclassification ofLysobacter thermophilus Weiet al2012 asVulcaniibacterium thermophilum comb. nov.Antonie Van Leeuwenhoek. 2013, Sep; 104(3):369-376. doi: 10.1007/s10482-013-9959-4;

22. Wanzeng Ren, Feng Zhang, Xinyi Yang, Shukun Tang, Hong Ming, Enmin Zhou, Yirui Yin,Wen-Jun Li*. Purification and Properties of a SDS-resistant Xylanase from halophilicStreptomonospora sp. YIM 90494.Cellulose. 2013, 20 (4): 1947-1955. doi: 10.1007/s10570-013-9953-z;

23. Yan-Qing Duan, Song-Tao He, Qing-Qing Li, Ming-Feng Wang, Wen-Yuan Wang, Wei Zhe*, Yong-Hong Cao, Ming-He Mo, Yu-Long Zhai,Wen-Jun Li*.Lysinibacillus tabacifoliisp. nov., a novel endophytic bacterium isolated from 烟草属 tabacum leaves.Journal of Microbiology. 2013, 51(3): 289-294;

24. Bing-Bing Liu, Shu-Kun Tang, Heng-Lin Cui, Yong-Guang Zhang, Li Li, Yuan-Ming Zhang, Li-Li Zhang,Wen-Jun Li*.Halopelagius fulvigenes sp. nov., a halophilic archaeon isolated from Qijiaojing lake in Xijiang, northwest of China.Int. J. Syst. Evol. Microbiol.2013, 63(6): 2192-2196;

25. Dao-Feng Zhang, Wei Chen, Jie He, Xiao-Mei Zhang, Zi-jun Xiong, Maloy Kumar Sahu, Kannan Sivakumar,Wen-jun Li*.Saccharomonospora oceanisp. nov., isolated from marine sediments in Little Andaman, India.Antonie Van Leeuwenhoek. 2013, 103:1377–1384, DOI 10.1007/s10482-013-9918-0;

26. Salam Nimaichand, K. Tamreihao, Ling-Ling Yang, Wen-Yong Zhu, Yong-Guang Zhang, Li Li, Shu-Kun Tang, Debananda S. Ningthoujam andWen-Jun Li*.链霉菌属 hundungensis sp. nov., a novel actinomycete with antifungal activity and 植物界 growth promoting traits.Journal of Antibiotics. 2013 Apr; 66(4):205-209, doi: 10.1038/ja.2012;

27. Yang Feng, Xuexiu Chang, Lixing Zhao,Xiuping Li,Wenjun Li, Yi Jiang. Nanaomycin A methyl ester, an actinomycete metabolite: Algicidal activity and the physiological response of Microcystis aeruginosa.Ecological Engineering. 2013, 53(4): 306-312;

28. Hong-Wei Li, Xiao-Yang Zhi, Ji-Cheng Yao, Yu Zhou, Shu-Kun Tang, Hans-Peter Klenk, Jiao Zhao,Wen-Jun Li*.Comparative Genomic Analysis of the Genus拟诺卡氏菌属 Provides New Insights into its Genetic Mechanisms of Environmental Adaptability.PLoS ONE. 2013, 8(4): e61528. doi:10.1371/journal.pone.0061528;

29. Zhao-Qi Song, Feng-Ping Wang, Xiao-Yang Zhi, Jin-Quan Chen, En-Min Zhou, Feng Liang, Xiang Xiao, Shu-Kun Tang, Hong-Chen Jiang, Chuanlun L. Zhang, Hailiang Dong, andWen-Jun Li*. Bacterial and archaeal diversities in Yunnan and Tibetan hot springs, China.Environ Microbiol. 2013, Apr;15(4):1160-1175. doi:10.1111/1462-2920.12025;

30. Tian SZ, Pu X, Luo G, Zhao LX, Xu LH,Li WJ, Luo Y. Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from a Halophilic Actinomycete 拟诺卡氏菌属 gilva YIM 90087.J Agric Food Chem. 2013, Mar 27. 61(12): 3006-3012. doi: 10.1021/jf400718w;

31. Ying Xu, Xin-Peng Tian, Yu-Juan Liu, Jie Li, Chang-Jin Kim, Hao Yin,Wen-Jun Li*, and Si Zhang*.Sinomicrobium oceani gen. nov., sp. nov., a novel member of the familyFlavobacteriaceae isolated from the south China Sea.Int. J. Syst. Evol. Microbiol. 2013,63 (3): 1045-1050;

32. Zhiying Wang, Peng Fu, Peipei Liu, Pei Wang, Jiabo Hou,Wenjun Li* andWeiming Zhu*. New 2-Pyrones from Alkalophilic Actinomycete,Nocardiopsis alkaliphilasp. nov. YIM 80379.化学 \u0026 Biodiversity.2013, 10:283-287;

33. Tian-Tian Yu, Ji-Cheng Yao, Hong Ming, Yi-Rui Yin, En-Min Zhou, Min-Jiao Liu, Shu-Kun Tang andWen-Jun Li*.栖热菌属 tengchongensissp. nov., isolated from a geothermally heated soil sample in Tengchong, Yunnan, south-west China.Antonie Van Leeuwenhoek. 2013, 103(3): 513-518;

34. Weiguo Hou, Shang Wang, Hongchen Jiang, Hailiang 越南盾*, Brandon R. Briggs, Joseph P. Peacock, Qiuyuan Huang, Liuquin Huang, Geng Wu, Xiaoyang Zhi,Wenjun Li, Jeremy A. Dodsworth, Brian P. Hedlund, Chuanlun Zhang, Hilairy E. Hartnett, Paul Dijkstra, and Bruce A. Hungate. A comprehensive census of microbial diversity in hot springs of Tengchong, Yunnan Province, China using 16S rRNA gene pyrosequencing.PLoS ONE 2013, 8(1): e53350. doi:10.1371/journal.pone.0053350;

35. Jie Li, Guo-Zhen Zhao, Ajit Varma, Sheng Qin, Zhi Xiong, Hai-Yu Huang, Wen-Yong Zhu, Li-Xing Zhao, Li-Hua Xu, Si Zhang,Wen-Jun Li*. An endophytic Pseudonocardia 物种 induces the production of artemisinin in 蒿属 annua.,PLOS One,2012, 7(12): e51410. doi:10.1371/journal.pone.0051410

36. Tian-Tian Yu, Bing-Huo Zhang, Ji-Cheng Yao, Shu-Kun Tang, En-Min Zhou, Yi-Rui Yin, Da-Qiao Wei, Hong Ming andWen-Jun Li*.Lihuaxuella thermophila gen. nov., sp. nov., isolated from a geothermal soil sample in Tengchong, Yunnan, south-west China.Antonie Van Leeuwenhoek. 2012, Nov, 102(4):711-718;

37. Guo-Zhen Zhao, Jie Li, Yu-Li Qin, Cui-Ping Miao, Da-Qiao Wei, Si Zhang, Li-Hua Xu andWen-Jun Li*.Pseudonocardia antimicrobica sp. nov., a novel endophytic actinomycete associated with 蒿属 annua L. (sweet wormwood).Journal of Antibiotics. 2012, 65(10): 469-472;

38. Sheng Qin, Hua-Hong Chen, Guo-Zhen Zhao, Jie Li, Wen-Yong Zhu,Li-Hua Xu, Ji-Hong Jiang,Wen-Jun Li*. Abundant and diverse endophytic 放线菌 associated with medicinal 植物界Maytenus austroyunnanensis in Xishuangbanna tropical rainforest revealed by culture-dependent and culture-independent methods.Environmenal Microbiology Report. 2012 Oct;4(5):522-31. doi: 10.1111/j.1758-2229.2012.00357.x. Epub 2012 May 24.;

39. Jie Li, Guo-Zhen Zhao, Li-Juan Long, Fa-Zuo Wang, Xin-Peng Tian, Si Zhang, andWen-Jun Li*.红球菌属 nanhaiensissp. nov., a novel actinobacterium isolated from marine sediment of the South China Sea.Int. J. Syst. Evol. Microbiol. 2012, 62(10): 2517-2521;

40. Wen-Yong Zhu, Li-Xing Zhao, Guo-Zhen Zhao, Xue-Wei Duan, Sheng Qin, Jie Li, Li-Hua Xu, andWen-Jun Li*.Plantactinospora endophytica sp. nov., a novel actinomycete isolated fromCamptotheca acuminata Decne., reclassification ofActinaurispora siamensis asPlantactinospora siamensis comb. nov. and emended description of the genusPlantactinospora.Int. J. Syst. Evol. Microbiol.2012, 62(10): 2435-2442;

41. En-Min Zhou, Ling-Ling Yang, Zhao-Qi Song, Tian-Tian Yu, Guo-Xing Nie, Hong Ming, Yu Zhou, Shu-Kun Tang, andWen-Jun Li*.Thermocatellispora tengchongensisgen. nov., sp. nov., a new member of the familyStreptosporangiaceae.Int. J. Syst. Evol. Microbiol. 2012, 62(10): 2417-2423;

42. Ying Xu, Jie He, Xin-Peng Tian, Jie Li, Ling-Ling Yang, Qiong Xie, Shu-Kun Tang, Yi-Guang Chen, Si Zhang, andWen-Jun Li*.链霉菌属 glycovorans sp. nov.,Streptomyces xishensis sp. nov. andStreptomyces abyssalis sp. nov. isolated from the Xisha Islands Sea area in the South China Sea.Int. J. Syst. Evol. Microbiol. 2012, 62(10): 2371-2377;

43. Feng Zhang, Jiu-Jiu Chen, Wan-Zeng Ren, Lian-Bing Lin, Yu Zhou , Xiao-Yang Zhi, Shu-Kun Tan,Wen-Jun Li*. Cloning, expression and characterization of an alkaline thermostable GH11 xylanase from Thermobifida halotolerans YIM 90462T.J Ind Microbiol Biot. 2012, 39:1109-1116;

44. En-Min Zhou, Shu-Kun Tang, Carsten Sjøholm, Zhao-Qi Song, Tian-Tian Yu, Ling-Ling Yang, Hong Ming, Guo-Xing Nie \u0026Wen-Jun Li*.Thermoactinospora rubra gen. nov., sp. nov., a thermophilic actinomycete isolated from Tengchong, Yunnan province, south-west China.Antonie van Leeuwenhoek. 2012, June;102(1):177-185.

45. Klenk HP, Lu M, Lucas S, Lapidus A, Copeland A, Pitluck S, Goodwin LA, Han C, Tapia R, Brambilla EM, Pötter G, Land M, IVanova N, Rohde M, Göker M, Detter JC,Li WJ, Kyrpides NC, Woyke T. Genome sequence of the ocean sediment bacterium Saccharomonospora marina type strain (XMU15(T)).Stand Genomic Sci. 2012 May 25;6(2):265-75.

46. Ling-Ling Yang, Tao Ao, Xing-Hong Wang, Jie He, Hans-Peter Klenk, Shu-Kun Tang, andWen-Jun Li*. Proposal ofIntrasporangium mesophilum sp. nov., and reclassification ofHumihabitans oryzae Kageyama et al. 2007 asIntrasporangium oryzae comb. nov.Int. J. Syst. Evol. Microbiol. 2012, 62(5): 1037-1041;

47. Jie Li, Guo-Zhen Zhao, Hai-Yu Huang, Sheng Qin, Wen-Yong Zhu, Li-Xing Zhao, Li-Hua Xu, Si Zhang,Wen-Jun Li* and Gary Strobel. Isolation and Characterization of culturable endophytic 放线菌 associated withArtemisia annua L.Antonie Van Leeuwenhoek. 2012, 101(1): 515-527;

48. Junying Ma, Dianguang Zuo,Yongxiang Song, Bo Wang, Hongbo Huang,Yueliang Yao,Wenjun Li, Si Zhang, Changsheng Zhang, Jianhua Ju. Characterization of a Single Gene Cluster that is Responsible for Methylpendolmycin and Pendolmycin Biosynthesis in the Deep Sea bacteriumMarinactinospora thermotolerans.Chem Biochem. 2012, Mar, 13(4): 547-552;

49. Feng Zhang, Song-Nan Hu, Jiu-Jiu Chen, Lian-Bing Lin, YunLin Wei, Shu-Kun Tang, Li-Hua Xu,Wen-Jun Li*.Purification and characterization of a thermotable xylanase from a salt-tolerant Thermobifida halotolerans YIM 90462.Process Biochemistry. 2012, 47 (2): 225-228;

50. Qinghua Zhu, Jun Li, Junying Ma, Minghe Luo, Bo Wang, Hongbo Huang, Xinpeng Tian,Wenjun Li, Si Zhang, Changsheng Zhang, and Jianhua Ju. Discovery and Engineered Overproduction of Antimicrobial Nucleoside Antibiotic A201A from Deep Sea Marine ActinomyceteMarinactinospora thermotolerans SCSIO 00652.Antimicrobial Agents and Chemotherapy. 2012, Jan;56(1):110-114;

51. Xiao-Yang Zhi, Wei Zhao,Wen-Jun Li and Guo-Ping Zhao*. Prokaryotic systematics in the genomics era.Antonie Van Leeuwenhoek. 2012, 101(1): 21-34;

52. Jing Li, Xin-Peng Tian, Tian-Jiao Zhu, Ling-Ling Yang,Wen-Jun Li*.Streptomyces fildesensis sp. nov., a novel streptomycete isolated from Antarctic soil.Antonie van Leeuwenhoek. 2011, Nov, 100(4): 537-543;

53. Feng Zhang, Jiu-Jiu Chen, Wan-Zeng Ren, Guo-Xing Nie, Hong Ming, Shu-Kun Tang,Wen-Jun Li*.Cloning, expression and characterization of an alkaline thermostableGH9 endoglucanase fromThermobifida halotoleransYIM 90462.Bioresource Technology. 2011, Nov, 102 (21): 10143-10146, doi: 10.1016/j.biortech.2011.08.019;

54. Li, Sumei; Tian, Xinpeng; Niu, Siwen; Zhang, Wenjun; Chen, Yuchan; Zhang, Haibo; Yang, Xianwen; Zhang, Weimin;Li, Wenjun; Zhang, Si; Ju, Jianhua; Zhang, Changsheng. Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea ActinomycetePseudonocardia sp. SCSIO 01299.Mar. Drugs2011, 9 (8): 1428-1439.

55. Jin-Wei Zheng, Yi-Guang Chen, Jun Zhang, Ying-Ying Ni,Wen-Jun Li*, Jian He, and Shun-Peng Li. Description ofCatellibacterium caenisp. nov., reclassification ofRhodobacter changlensis Anil Kumar et al. 2007 asCatellibacterium changlense comb. nov. and emended description of the genusCatellibacterium.Int. J. Syst. Evol. Microbiol. 2011, 61(8): 1921-1926;

56. Shu-Kun Tang, Yun Wang, Hans-Peter Klenk, Rong Shi, Kai Lou, YunJiao Zhang, Chao Chen, Ji-Sheng Ruan, andWen-Jun Li*.Actinopolyspora alba sp. nov. andActinopolyspora erythraea sp. nov., isolated from a salt lake in China, and reclassification ofActinopolyspora iraqiensis (Ruan et al 1994) asSaccharomonospora halophila comb. nov.Int. J. Syst. Evol. Microbiol. 2011, 61(7): 1693-1698;

57. David P. Labeda, Michael Goodfellow, Jongsik Chun, Xiao-Yang Zhi, andWen-Jun Li. Reassessment of the Systematics within the suborderPseudonocardineae: Elimination of the familyActinosynnemataceae (Labeda and Kroppenstedt 2000) Zhi et al. 2009 and emendation of the familyPseudonocardiaceae (Embley et al. 1989) Zhi et al. 2009.Int. J. Syst. Evol. Microbiol. 2011, 61(6): 1259-1264;

58. Yu-Qin Zhang, Hong-Yu Liu, Li-Yan Yu, Jae-Chan Lee, Dong-Jin Park, Chang-Jin Kim, Li-Hua Xu, Cheng-Lin Jiang, andWen-Jun Li*.Sinosporangium album gen. nov., sp. nov., a new member of the suborderStreptosporangineae.Int. J. Syst. Evol. Microbiol. 2011, 61(3): 592-597;

59. Sheng Qin, Ke Xing, Ji-Hong Jiang, Li-Hua Xu \u0026Wen-Jun Li*. Biodiversity, Bioactive natural products and Biotechnological potential of plant associated endophytic 放线菌AppliedMicrobiologyandBiotechnology. 2011, 89(3): 457-473;

60. Shu-Kun Tang, Xiao-Yang Zhi, Yun Wang, Rong Shi, Kai Lou, Li-Hua Xu, andWen-Jun Li*.Haloactinopolyspora albagen. nov. sp. nov., a novel halophilic filamentous actinomycete isolated from a salt lake in China, with proposal ofJiangellaceae fam. nov. andJiangellineae subord. nov.Int. J. Syst. Evol. Microbiol. 2011, 61(1): 194-200.

参考资料

李文均.中山大学生命科学学院.2021-12-15

中国科学院大学教师个人主页-李文均.中国科学院大学.2015-03-04

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